the validity of mri in evaluation of tumor response to neoadjuvant chemotherapy in locally advanced breast cancer

نویسندگان

mahboobeh abedi dept. of radiology, imam reza hospital, mashad university of medical sciences, mashhad, iran

donya farrokh dept. of radiology, imam reza hospital, mashad university of medical sciences, mashhad, iran

fatemeh homaei solid tumor treatment research center, mashad university of medical sciences, mashhad, iran

azadeh joulaee dept. of surgery, mahdieh hospital, shahid beheshti university of medical sciences, tehran, iran

چکیده

background: physical examination (pe) and breast mri are two of the current methods which have usually used in diagnosis of primary breast cancer. their accuracy in detection of: either complete response or presence of residual tumor, however, has not yet been established in patients who have been received neoadjuvant chemotherapy (nac). the purpose of this study was to evaluate the diagnostic accuracy of breast mri in assessment of residual neoplastic tissue after nac in patients with locally advanced breast cancer (labc). methods: twenty patients with labc have undergone contrast-enhanced mri before and after the nac. considering histology as the gold standard, the tumor sizes in mri and pe have compared with the histology results. we have calculated for all below: the accuracy, sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) for each of mri and physical examination, as well as pearson's correlation coefficients between the results of mri and pe, and their histology results. results: we have found an accuracy of 85% for mri with a sensitivity of 100%, a specificity of 50%, a ppv of 83.3%, and an npv of 100%. in addition, the accuracy for pe was 70% with a sensitivity of 71.4%, a specificity of 66.6%, a ppv of 83.3%, and an npv of 50%. in this study, the calculated pearson's correlation coefficient for mri and histology was 0.817 (p<0.0001) versus 0.26 (p=0.26) for correlation between pe and histology. conclusion: mri has higher sensitivity but less specificity than pe for detection of residual tumor after nac in locally advanced breast carcinoma. also, the tumor size that has measured by mri had highly correlation with the histology.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Validity of MRI in Evaluation of Tumor Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer

BACKGROUND Physical Examination (PE) and breast MRI are two of the currentmethods which have usually used in diagnosis of primary breast cancer. Their accuracy in detection of: either complete response or presence of residual tumor, however, has not yet been established in patients who have been received Neoadjuvant Chemotherapy (NAC).The purpose of this study was to evaluate the diagnostic acc...

متن کامل

Response to neoadjuvant chemotherapy in locally advanced gastric and gastroesophageal cancer: Phase II clinical trial

Background: Gastric cancer is an important health problem across the world. Chemotherapy in combination with local treatment is standard treatment for locally advanced gastroesophageal cancers. The purpose of this investigation was evaluation of response and tolerability to neoadjuvant EOX regimen in locoregionally advanced gastric cancer. Materials and Methods: patients with locoregionally adv...

متن کامل

Association of tumor infiltration lymphocytes and complete pathological response in breast cancer patients under neoadjuvant chemotherapy

Background: The breast cancer is the most common type of cancer in Iran. Hence determination of the optimal treatment and the contributing factors are important. The main aim in current study was to determine the association between tumor infiltration of lymphocytes (TIL) and complete pathological response in breast cancer patients after neoadjuvant chemotherapy. Methods and materials: In this...

متن کامل

Early Prediction of Response to Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer Using Mri

Neoadjuvant chemotherapy (NAC) is the favored treatment of choice among locally advanced breast cancer patients because it significantly increases the possibility of breast-conserving surgery. However, for non-responders, an early prediction of response to NAC is essential. The purpose of this study was to determine whether an early prediction of response to NAC is possible using MRI. Eleven br...

متن کامل

Thermal tomography for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer

BACKGROUND & AIMS This study aims to analyze the feasibility and predictive value of thermal tomography (TT) for monitoring early treatment response in patients with locally advanced breast cancer (LABC) receiving neoadjuvant chemotherapy (NAC). METHODS Patients with LABC who were due to receive six cycles of NAC were examined by TT prior to NAC, the second cycle of NAC, the fourth cycle of N...

متن کامل

Molecular subtypes and tumor response to neoadjuvant chemotherapy in patients with locally advanced breast cancer.

OBJECTIVE Pathologic complete response (pCR) is the most predictive factor for patients with neoadjuvant chemotherapy and we investigated the rate of pCR according to molecular subtypes defined by immunohistochemical staining. METHODS Our subjects comprised 257 breast cancer patients who received 3 cycles of anthracycline/taxane-based neoadjuvant chemotherapy. The patients were classified int...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of cancer prevention

جلد ۶، شماره ۱، صفحات ۲۸-۳۵

کلمات کلیدی
[ ' l o c a l l y a d v a n c e d ' , ' b r e a s t c a n c e r ' , ' m a g n e t i c r e s o n a n c e i m a g i n g ( m r i ) ' , ' n e o a d j u v a n t ' , ' c h e m o t h e r a p y p l e a s e c i t e t h i s a r t i c l e a s ' , ' a b e d i m ' , ' f a r r o k h d ' , ' h o m a e i s h a n d i z f ' , ' j o u l a e e a ' , ' a n b i a e e r ' , ' z a n d i b ' , ' g i t y m ' , ' s a y a h h r ' , ' a b e d i m s . t h e v a l i d i t y o f m r i i n e v a l u a t i o n o f t u m o r r e s p o n s e t o n e o a d j u v a n t c h e m o t h e r a p y i n l o c a l l y a d v a n c e d b r e a s t c a n c e r . i r a n j c a n c e r p r e v . 2 0 1 3 ' , ' 6 ( 1 ) ' , 2 8 , ' 3 5 . r e f e r e n c e s 1 . v a l e r o v ' , ' b u z d a r a u ' , ' h o r t o b a g y i g n . l o c a l l y a d v a n c e d b r e a s t c a n c e r . o n c o l o g i s t . 1 9 9 6 ' , 1 , 8 , ' 1 7 . 2 . s z é k e l y b ' , ' s z e n t m á r t o n i g ' , ' k u l k a j ' , ' s z á s z a m ' , ' l a n g m á r z ' , ' d a n k m . p r i m a r y s y s t e m i c t h e r a p y i n b r e a s t c a n c e r ' , ' a n u p d a t e f o r g y n e c o l o g i c o n c o l o g i s t s . e u r j g y n a e c o l o n c o l . 2 0 1 1 ' , ' 3 2 ( 6 ) ' , 6 3 6 , ' 4 1 . 3 . k u e r e r h m ' , ' n e w m a n l a ' , ' s m i t h t l ' , ' a m e s f c ' , ' h u n t k k ' , ' d h i n g r a k ' , ' e t a l . c l i n i c a l c o u r s e o f b r e a s t c a n c e r p a t i e n t s w i t h c o m p l e t e p a t h o l o g i c p r i m a r y t u m o r a n d a x i l l a r y l y m p h n o d e r e s p o n s e t o d o x o r u b i c i n ' , ' b a s e d n e o a d j u v a n t c h e m o t h e r a p y . j c l i n o n c o l . 1 9 9 9 f e b ' , ' 1 7 ( 2 ) ' , 4 6 0 , ' 9 . 4 . m a n i s ' , ' c h e n y ' , ' a r l i n g h a u s l r ' , ' l i x ' , ' c h a k r a v a r t h y a b ' , ' b h a v e s r ' , ' e t a l . e a r l y p r e d i c t i o n o f t h e r e s p o n s e o f b r e a s t t u m o r s t o n e o a d j u v a n t c h e m o t h e r a p y u s i n g q u a n t i t a t i v e m r i a n d m a c h i n e l e a r n i n g . a m i a a n n u s y m p p r o c . 2 0 1 1 ' , 2 0 1 1 , 8 6 8 , ' 7 7 . 5 . f r a n k l i n j m ' , ' a n d e r s o n e m ' , ' g l e e s o n f v . m r i f e a t u r e s o f t h e c o m p l e t e h i s t o p a t h o l o g i c a l r e s p o n s e o f l o c a l l y a d v a n c e d r e c t a l c a n c e r t o n e o a d j u v a n t c h e m o r a d i o t h e r a p y . c l i n r a d i o l . 2 0 1 2 j u n ' , ' 6 7 ( 6 ) ' , 5 4 6 , ' 5 2 . 6 . p r a t i r ' , ' m i n a m i c a ' , ' g o r n b e i n j a ' , ' d e b r u h l n ' , ' c h u n g d ' , ' c h a n g h r . a c c u r a c y o f c l i n i c a l e v a l u a t i o n o f l o c a l l y a d v a n c e d b r e a s t c a n c e r i n p a t i e n t s r e c e i v i n g n e o a d j u v a n t c h e m o t h e r a p y . c a n c e r . 2 0 0 9 m a r 1 5 ' , ' 1 1 5 ( 6 ) ' , 1 1 9 4 , ' 2 0 2 . 7 . h a r m s s e . t e c h n i c a l r e p o r t o f t h e i n t e r n a t i o n a l w o r k i n g g r o u p o n b r e a s t m r i . j m a g n r e s o n i m a g i n g . 1 9 9 9 d e c ' , ' 1 0 ( 6 ) ' , ' 9 7 9 . 8 . l i b e r m a n l ' , ' m o r r i s e a ' , ' l e e m j ' , ' k a p l a n j b ' , ' l a t r e n t a l r ' , ' m e n e l l j h ' , ' e t a l . b r e a s t l e s i o n s d e t e c t e d o n m r i m a g i n g ' , ' f e a t u r e s a n d p o s i t i v e p r e d i c t i v e v a l u e . a j r a m j r o e n t g e n o l . 2 0 0 2 j u l ' , ' 1 7 9 ( 1 ) ' , 1 7 1 , ' 8 . 9 . b r o w n j ' , ' s m i t h r c ' , ' l e e c h . i n c i d e n t a l e n h a n c i n g l e s i o n s f o u n d o n m r i m a g i n g o f t h e b r e a s t . a j r a m j r o e n t g e n o l . 2 0 0 1 m a y ' , ' 1 7 6 ( 5 ) ' , 1 2 4 9 , ' 5 4 . 1 0 . l o n d e r o v ' , ' b a z z o c c h i m ' , ' d e l f r a t e c ' , ' p u g l i s i f ' , ' d i l o r e t o c ' , ' f r a n c e s c u t t i g ' , ' e t a l . l o c a l l y a d v a n c e d b r e a s t c a n c e r ' , ' c o m p a r i s o n o f m a m m o g r a p h y ' , ' s o n o g r a p h y a n d m r i m a g i n g i n e v a l u a t i o n o f r e s i d u a l d i s e a s e i n w o m e n r e c e i v i n g n e o a d j u v a n t c h e m o t h e r a p y . e u r r a d i o l . 2 0 0 4 a u g ' , ' 1 4 ( 8 ) ' , 1 3 7 1 , ' 9 . 1 1 . c h a g p a r a b ' , ' m i d d l e t o n l p ' , ' s a h i n a a ' , ' d e m p s e y p ' , ' b u z d a r a u ' , ' m i r z a a n ' , ' e t a l . a c c u r a c y o f p h y s i c a l e x a m i n a t i o n ' , ' u l t r a s o n o g r a p h y ' , ' a n d m a m m o g r a p h y i n p r e d i c t i n g r e s i d u a l p a t h o l o g i c t u m o r s i z e i n p a t i e n t s t r e a t e d w i t h n e o a d j u v a n t c h e m o t h e r a p y . a n n s u r g . 2 0 0 6 f e b ' , ' 2 4 3 ( 2 ) ' , 2 5 7 , ' 6 4 . 1 2 . b h a t t a c h a r y y a m ' , ' r y a n d ' , ' c a r p e n t e r r ' , ' v i n n i c o m b e s ' , ' g a l l a g h e r c j . u s i n g m r i t o p l a n b r e a s t ' , ' c o n s e r v i n g s u r g e r y f o l l o w i n g n e o a d j u v a n t c h e m o t h e r a p y f o r e a r l y b r e a s t c a n c e r . b r j c a n c e r . 2 0 0 8 j a n 2 9 ' , ' 9 8 ( 2 ) ' , 2 8 9 , ' 9 3 . 1 3 . s c h l o s s b a u e r t ' , ' r e i s e r m ' , ' h e l l e r h o f f k . [ i m p o r t a n c e o f m a m m o g r a p h y ' , ' s o n o g r a p h y a n d m r i f o r s u r v e i l l a n c e o f n e o a d j u v a n t c h e m o t h e r a p y f o r l o c a l l y a d v a n c e d b r e a s t c a n c e r ] . r a d i o l o g e . 2 0 1 0 n o v ' , ' 5 0 ( 1 1 ) ' , 1 0 0 8 , ' 1 3 . 1 4 . w a s i f n ' , ' g a r r e a u j ' , ' t e r a n d o a ' , ' k i r s c h d ' , ' m u n d d f ' , ' g i u l i a n o a e . m r i v e r s u s u l t r a s o n o g r a p h y a n d m a m m o g r a p h y f o r p r e o p e r a t i v e a s s e s s m e n t o f b r e a s t c a n c e r . a m s u r g . 2 0 0 9 o c t ' , ' 7 5 ( 1 0 ) ' , 9 7 0 , ' 5 . 1 5 . b a l u ' , ' m a e s t r o c ' , ' c h a p e l l i e r c ' , ' b l e u s e a ' , ' c h a n a l e t i ' , ' c h a u v e l c ' , ' l a r g i l l i e r r . i m a g i n g i n e v a l u a t i o n o f r e s p o n s e t o n e o a d j u v a n t b r e a s t c a n c e r t r e a t m e n t b e n e f i t s o f m r i . b r e a s t c a n c e r r e s t r e a t . 2 0 0 2 m a r ' , ' 7 2 ( 2 ) ' , 1 4 5 , ' 5 2 . 1 6 . a b r a h a m d c ' , ' j o n e s r c ' , ' j o n e s s e ' , ' c h e e k j h ' , ' p e t e r s g n ' , ' k n o x s m ' , ' e t a l . e v a l u a t i o n o f n e o a d j u v a n t c h e m o t h e r a p e u t i c r e s p o n s e o f l o c a l l y a d v a n c e d b r e a s t c a n c e r b y m a g n e t i c r e s o n a n c e i m a g i n g . c a n c e r . 1 9 9 6 j u l 1 ' , ' 7 8 ( 1 ) ' , 9 1 , ' 1 0 0 . 1 7 . c o c c o n i g ' , ' d i b l a s i o b ' , ' a l b e r t i g ' , ' b i s a g n i g ' , ' b o t t i e ' , ' p e r a c c h i a g . p r o b l e m s i n e v a l u a t i n g r e s p o n s e o f p r i m a r y b r e a s t c a n c e r t o s y s t e m i c t h e r a p y . b r e a s t c a n c e r r e s t r e a t . 1 9 8 4 ' , ' 4 ( 4 ) ' , 3 0 9 , ' 1 3 . 1 8 . w u l m ' , ' h u j n ' , ' g u h y ' , ' h u a j ' , ' c h e n j ' , ' x u j r . c a n d i f f u s i o n ' , ' w e i g h t e d m r i m a g i n g a n d c o n t r a s t ' , ' e n h a n c e d m r i m a g i n g p r e c i s e l y e v a l u a t e a n d p r e d i c t p a t h o l o g i c a l r e s p o n s e t o n e o a d j u v a n t c h e m o t h e r a p y i n p a t i e n t s w i t h b r e a s t c a n c e r ? b r e a s t c a n c e r r e s t r e a t . 2 0 1 2 a p r 4 . 1 9 . l i u y h ' , ' y e j m ' , ' x u l ' , ' h u a n g q y ' , ' z h a o j x ' , ' d u a n x n ' , ' e t a l . e f f e c t i v e n e s s o f d y n a m i c c o n t r a s t ' , ' e n h a n c e d m a g n e t i c r e s o n a n c e i m a g i n g i n e v a l u a t i n g c l i n i c a l r e s p o n s e s t o n e o a d j u v a n t c h e m o t h e r a p y i n b r e a s t c a n c e r . c h i n m e d j ( e n g l ) . 2 0 1 1 j a n ' , ' 1 2 4 ( 2 ) ' , 1 9 4 , ' 8 . 2 0 . c r o s h a w r ' , ' s h a p i r o ' , ' w r i g h t h ' , ' s v e n s s o n e ' , ' e r b k ' , ' j u l i a n t . a c c u r a c y o f c l i n i c a l e x a m i n a t i o n ' , ' d i g i t a l m a m m o g r a m ' , ' u l t r a s o u n d ' , ' a n d m r i i n d e t e r m i n i n g p o s t n e o a d j u v a n t p a t h o l o g i c t u m o r r e s p o n s e i n o p e r a b l e b r e a s t c a n c e r p a t i e n t s . a n n s u r g o n c o l . 2 0 1 1 o c t ' , ' 1 8 ( 1 1 ) ' , 3 1 6 0 , ' 3 . 2 1 . r o s e n e l ' , ' b l a c k w e l l k l ' , ' b a k e r j a ' , ' s o o m s ' , ' b e n t l e y r c ' , ' y u d ' , ' e t a l . a c c u r a c y o f m r i i n t h e d e t e c t i o n o f r e s i d u a l b r e a s t c a n c e r a f t e r n e o a d j u v a n t c h e m o t h e r a p y . a j r a m j r o e n t g e n o l . 2 0 0 3 n o v ' , ' 1 8 1 ( 5 ) ' , 1 2 7 5 , ' 8 2 . 2 2 . d o s e ' , ' s c h w a r z j ' , ' t i l i n g r ' , ' a v r i l ' , ' s a s s e n s ' , ' m a h n e r s ' , ' l e b e a u a ' , ' w e b e r c ' , ' e t a l . a s s e s s m e n t o f r e s i d u a l t u m o u r b y f d g ' , ' p e t ' , ' c o n v e n t i o n a l i m a g i n g a n d c l i n i c a l e x a m i n a t i o n f o l l o w i n g p r i m a r y c h e m o t h e r a p y o f l a r g e a n d l o c a l l y a d v a n c e d b r e a s t c a n c e r . b r j c a n c e r . 2 0 1 0 j a n 5 ' , ' 1 0 2 ( 1 ) ' , 3 5 , ' 4 1 . e p u b 2 0 0 9 n o v 1 7 . 2 3 . c h o i j h ' , ' l i m h i ' , ' l e e s k ' , ' k i m w w ' , ' k i m s m ' , ' c h o e . t h e r o l e o f p e t c t t o e v a l u a t e t h e r e s p o n s e t o n e o a d j u v a n t c h e m o t h e r a p y i n a d v a n c e d b r e a s t c a n c e r ' , ' c o m p a r i s o n w i t h u l t r a s o n o g r a p h y a n d m a g n e t i c r e s o n a n c e i m a g i n g . j s u r g o n c o l . 2 0 1 0 o c t 1 ' , ' 1 0 2 ( 5 ) ' , 3 9 2 , ' 7 . 2 4 . p a r k j s ' , ' m o o n w k ' , ' l y o u c y ' , ' c h o n ' , ' k a n g k w ' , ' c h u n g j k . t h e a s s e s s m e n t o f b r e a s t c a n c e r r e s p o n s e t o n e o a d j u v a n t c h e m o t h e r a p y ' , ' c o m p a r i s o n o f m a g n e t i c r e s o n a n c e i m a g i n g a n d 1 8 f ' , ' f l u o r o d e o x y g l u c o s e p o s i t r o n e m i s s i o n t o m o g r a p h y . a c t a r a d i o l . 2 0 1 1 f e b 1 ' , ' 5 2 ( 1 ) ' , 2 1 , ' 8 . 2 5 . w a n g y ' , ' z h a n g c ' , ' l i u j ' , ' h u a n g g . i s 1 8 f ' , ' f d g p e t a c c u r a t e t o p r e d i c t n e o a d j u v a n t t h e r a p y r e s p o n s e i n b r e a s t c a n c e r ? a m e t a ' , ' a n a l y s i s . b r e a s t c a n c e r r e s t r e a t . 2 0 1 2 j a n ' , ' 1 3 1 ( 2 ) ' , 3 5 7 , ' 6 9 . e p u b 2 0 1 1 s e p 3 0 . ' ]

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023